Overview

This project is a physiologically based pharmacokinetic modelling study of tirzepatide, represented as an SBML-based ordinary differential equation system.

Scientific question

How can curated clinical measurements and physiological structure be combined in a reproducible model of tirzepatide absorption, distribution and elimination?

Model and method

The work uses a compartmental PBPK model encoded as coupled ordinary differential equations. Model parameters are estimated against curated clinical measurements, and the model is distributed in an interoperable SBML-based form.

  1. Curated clinical measurements
  2. Physiological model structure
  3. SBML / ODE implementation
  4. Parameter optimization
  5. Simulation and diagnostics
  6. Reproducible model output
Conceptual workflow schematic; this is not a result figure.

Inputs

  • curated public clinical pharmacokinetic measurements;
  • physiological compartment structure;
  • model parameters and parameter bounds.

Outputs

  • simulated concentration–time behaviour;
  • estimated model parameters and diagnostics;
  • an interoperable model and archived research output.

My contribution

During a research internship, I developed the PBPK model using curated clinical data and parameter optimization.

Provenance

The model originated during a research internship at the Institute for Biology, Humboldt-Universität zu Berlin, and is presented as a jointly authored public Zenodo model output.

Scope and limitations

This is a research model, not a clinical decision-support system. Its behaviour depends on the available clinical measurements, compartment assumptions and fitted parameterization.

Resources