Design Principles¶
The system is built around a few core principles.
Biological interpretability¶
Every component maps back to biochemical meaning.
- EC50 reflects sensitivity
- Δmax reflects effect size
- NSS integrates meaningful signals
Robustness¶
The pipeline is designed for noisy experimental data.
- Monotonic smoothing
- Robust scaling
- Conservative filtering
Multi-scale integration¶
The system connects:
- molecular level (sequence)
- protein level (dose–response)
- system level (pathways, networks)
- latent structure (hidden patterns)
Efficiency¶
- Parallel processing
- Caching at multiple levels
- Modular design
Extensibility¶
The architecture allows extension at:
- modeling layer
- scoring functions
- network inference
- sequence models
These principles ensure the system is both practical and scientifically grounded.